Name 요시노리 Ohsumi Yoshinor
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요시노리-Ohsumi Yoshinori,교수,노벨상,Japan
오스미 요시노리 (大隅良典, Ohsumi
Yoshinori) 대학교수, 노벨 생리의학상(2016)

[출생] 1945년 2월 9일, 일본
[소속] 도쿄공업대학 (명예교수), 도쿄공업대학
과학기술창성연구원 (특임교수)

~ 1972 도쿄대학 대학원 농예화학과 박사
1969 ~ 1972 도쿄대학 대학원 상관이화학 박사
도쿄대학 대학원 상관이화학 석사
~ 1967 도쿄대학 기초과학과 학사

2016 ~ 일본 도쿄공업대학 과학기술창성연구원
2014 ~ 일본 도쿄공업대학 명예교수
2009 일본 도쿄공업대학 통합연구원 프론티어연
구기구 특임교수
2004 일본 자연과학연구기구 기초생물학연구소
1996 일본 오카자키 국립공동연구기구 기초생물
학연구소 교수
1988 일본 도쿄대학 교양학부 조교수
1986 일본 도쿄대학 자연과학부 강사
1977 일본 도쿄대학 자연과학부 연구원

2016년 10월 3일 노벨상, 생리의학상
2013 톰슨로이터 인용상
2012 교토상
2009 아사히상
2006 제96회 일본학사원상

오스미 요시노리(大隅 良典, 1945년 2월 9일 ~ )
는 일본의 생물학자이며, 2016년 노벨 생리학·
의학상 수상자이다.

[글로벌이코노믹 이동화 기자] 3일 발표된 2016
년 노벨 생리의학상은 도쿄공업대학 오스미 요시
노리(大隅良典, 71세) 명예교수에게 돌아갔다.

스웨덴 한림원은 세포 내에서 손상된 단백질 등
을 분해하는 ‘오토 파지(autophagy)’ 구조를
해명한 공을 인정해 오스미 교수를 수상자로 선
정했다고 밝혔다.

NHK는 “일본인의 노벨상 수상은 3년 연속”이라
며 “미국 국적을 취득한 사람을 포함하면 25명
째이며, 생리의학상 수상은 지난해 오오무라 사
토시씨에게 이어 4명째”라고 보도했다.

Press Release

The Nobel Assembly at Karolinska Institutet
has today decided to award

the 2016 Nobel Prize in Physiology or


Yoshinori Ohsumi

for his discoveries of mechanisms for


This year's Nobel Laureate discovered and
elucidated mechanisms underlying autophagy,
a fundamental process for degrading and
recycling cellular components.

The word autophagy originates from the Greek
words auto-, meaning "self", and phagein,
meaning "to eat". Thus,autophagy
denotes "self eating". This concept emerged
during the 1960's, when researchers first
observed that the cell could destroy its own
contents by enclosing it in membranes,
forming sack-like vesicles that were
transported to a recycling compartment,
called the lysosome, for degradation.
Difficulties in studying the phenomenon
meant that little was known until, in a
series of brilliant experiments in the early
1990's, Yoshinori Ohsumi used baker's yeast
to identify genes essential for autophagy.
He then went on to elucidate the underlying
mechanisms for autophagy in yeast and showed
that similar sophisticated machinery is used
in our cells.

Ohsumi's discoveries led to a new paradigm
in our understanding of how the cell
recycles its content. His discoveries opened
the path to understanding the fundamental
importance of autophagy in many
physiological processes, such as in the
adaptation to starvation or response to
infection. Mutations in autophagy genes can
cause disease, and the autophagic process is
involved in several conditions including
cancer and neurological disease.
Yoshinori Ohsumi (大隅 良典) (born February
9, 1945) is a Japanese cell biologist
specializing in autophagy, is a professor in
Tokyo Institute of Technology 's Frontier
Research Center. He received the Kyoto Prize
for Basic Science in 2012.

On October 3, 2016, Yoshinori Ohsumi was
declared as the recipient of the 2016 Nobel
Prize in Physiology or Medicine for his
discoveries of mechanisms for autophagy.

Ohsumi was born February 9, 1945 in Fukuoka,
Japan. He received a B.Sci. in 1967 and a
D.Sci. in 1974, both from Tokyo University;
from 1974-77 he was a postdoctoral fellow at
the Rockefeller University in New York City.

He returned to The University of Tokyo in
1977 as a Research Associate; he was
appointed Lecturer there in 1986, and
promoted to Associate Professor in 1988. In
1996 he moved to the National Institute for
Basic Biology in Okazaki City, Japan. where
he was appointed Professor. From 2004 to
2009 he was also professor at the Graduate
University for Advanced Studies in Hayama,
Japan. In 2009 he transitioned to a three-
way appointment as Emeritus Professor at the
National Institute for Basic Biology and at
the Graduate University for Advanced
Studies, and a Professorship at the
University of Tokyo.

Fujihara Award, Fujihara Foundation of
Science (2005)
Japan Academy Prize, Japan Academy (2006)
Asahi Prize, Asahi Shimbun (2009)
Kyoto Prize for Basic Science (2012)
Gairdner Foundation International Award
International Prize for Biology (2015)
Keio Medical Science Prize (2015)
Wiley Prize in Biomedical Sciences (2016)
Nobel Prize in Physiology or Medicine (2016)

Mizushima, N; Noda, T; Yoshimori, T; Tanaka,
Y; Ishii, T; George, MD; Klionsky, DJ;
Ohsumi, M; Ohsumi, Y (24 September 1998). "A
protein conjugation system essential for
autophagy.". Nature. 395 (6700): 395–8. PMID
Kabeya, Y.; Mizushima, N.; Ueno, T.;
Yamamoto, A.; Kirisako, T.; Noda, T.;
Kominami, E.; Ohsumi, Y.; Yoshimori, T.
(2000). "LC3, a mammalian homologue of yeast
Apg8p, is localized in autophagosome
membranes after processing". The EMBO
Journal. 19 (21): 5720–5728.
doi:10.1093/emboj/19.21.5720. PMC 305793free
to read. PMID 11060023.
Kuma, A; Hatano, M; Matsui, M; Yamamoto, A;
Nakaya, H; Yoshimori, T; Ohsumi, Y;
Tokuhisa, T; Mizushima, N (23 December
2004). "The role of autophagy during the
early neonatal starvation period.". Nature.
432 (7020): 1032–6. PMID 15525940.
Ohsumi, Y (March 2001). "Molecular
dissection of autophagy: two ubiquitin-like
systems.". Nature reviews. Molecular cell
biology. 2 (3): 211–6. PMID 11265251.
Ichimura, Y; Kirisako, T; Takao, T; Satomi,
Y; Shimonishi, Y; Ishihara, N; Mizushima, N;
Tanida, I; Kominami, E; Ohsumi, M; Noda, T;
Ohsumi, Y (23 November 2000). "A ubiquitin-
like system mediates protein lipidation.".
Nature. 408 (6811): 488–92. PMID 11100732.


Cellular Components, Concept, influence(+) ~
(PIG: time-variant)

Positive Influence GRADE (PIG): C+

a b c d e f g h i j k l m n o p q r s t u v w x y z  0 1 2 3 4 5 6 7 8 9

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